MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation
Guerin C, Vinchent A, Fernandes M, Damour I, Laratte A, Tellier R, Estevam GO, Meneboo JP, Villenet C, Descarpentries C, Fraser JS, Figeac M, Cortot AB, Rouleau E, Tulasne D
Molecular Oncology,
2025
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Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
Estevam GO, Linossi EM, Rao J, Macdonald CM, Ravikumar A, Chrispens KM, Capra JA, Coyote-Maestas W, Pimentel H, Collisson EA, Jura N, Fraser JS
eLife,
2025
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Engineering of CRISPR-Cas PAM recognition using deep learning of vast evolutionary data
Nayfach S, Bhatnagar A, Novichkov A, Estevam GO, Kim N, Hill E, Ruffolo JA, Silverstein R, Gallagher J, Kleinstiver B, Meeske AJ, Cameron P, Madani A
Preprint,
2025
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Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain
Estevam GO, Linossi EM, Macdonald CM, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
eLife,
2024
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Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage
Rao J, Xin R, Macdonald CB, Howard M, Estevam GO, Yee SW, Wang M, Fraser JS, Coyote-Maestas W, Pimentel H
Genome Biology,
2024
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State of the structure address on MET receptor activation by HGF
Linossi EM, Estevam GO, Oshima M, Fraser JS, Collisson EA, Jura N
Biochemical Society Transactions,
2021
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